DEVELOPMENT AND OPTIMIZATION OF NUTRACEUTICAL FORMULATION CONTAINING CITICOLINE AND PIRACETAM
Asma B. Pathan*, Nita B. Pawar and Ahad J. Pathan
ABSTRACT
Development, Optimization and Evaluation of Citicoline and
Piracetam from their Formulation. The objective of present
investigations were to optimize different concentration of HPMC as
coating for taste masking. Citicoline, Piracetam and HPMC, distilled
water and methanol. Formulation was prepared by wet granulation
technique and evaluated for drug content, infrared spectroscopy,
scanning electron microscopy and in vitro dissolution study. The
purpose of this study was to develop and optimize taste masking
granule formulation for Piracetam using HPMC as a coating material.
Initially trials were done to optimize the concentration of HPMC on to
granules or its uniformity of size and Assay, varying the concentration
of HPMC as coating material. The cumulative drug release percentages
at 15, 30, and 35 min were the target responses and were restricted to 50%, 68%, and 98%
respectively. For formulation, the results suggests that considerable taste masking of
Piracetam was carried out by using 200 mg of HPMC and weight reduction was achieved as
compared to marketed formulation. Formulation of Citicoline and Piracetam were
successfully developed in this work.
Keywords: Citicoline, Piracetam, Taste Masking, Wet Granulation.
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