Abstract

DEVELOPMENT AND OPTIMIZATION OF NUTRACEUTICAL FORMULATION CONTAINING CITICOLINE AND PIRACETAM

Asma B. Pathan*, Nita B. Pawar and Ahad J. Pathan

ABSTRACT

Development, Optimization and Evaluation of Citicoline and Piracetam from their Formulation. The objective of present investigations were to optimize different concentration of HPMC as coating for taste masking. Citicoline, Piracetam and HPMC, distilled water and methanol. Formulation was prepared by wet granulation technique and evaluated for drug content, infrared spectroscopy, scanning electron microscopy and in vitro dissolution study. The purpose of this study was to develop and optimize taste masking granule formulation for Piracetam using HPMC as a coating material. Initially trials were done to optimize the concentration of HPMC on to granules or its uniformity of size and Assay, varying the concentration of HPMC as coating material. The cumulative drug release percentages at 15, 30, and 35 min were the target responses and were restricted to 50%, 68%, and 98% respectively. For formulation, the results suggests that considerable taste masking of Piracetam was carried out by using 200 mg of HPMC and weight reduction was achieved as compared to marketed formulation. Formulation of Citicoline and Piracetam were successfully developed in this work.

Keywords: Citicoline, Piracetam, Taste Masking, Wet Granulation.