Abstract

AMELEORATIVE EFFECT OF CRUDE EXTRACT OF HARIDRA ON EMPTY BLADDER OF INDUCED DIABETIC MODEL SWISS ALBINO MOUSE

Maurya D. K.*, Singh Royana and Singh K. N.

ABSTRACT

Background: The literatures of Ayurveda describe that Premeha (Diabetes Mellitus) is a disease of urinary System, which respond well to dried and cured rhizome of the Curcuma longa. The extensive perennial herb Haridra shows tremondus effect on Prameha when it’s crude extract is applied orally in combination with Kshaudra (Honey) and Amalki rasa (Emblica officinalis). Aims and Objectives: The current study aimed to show as an ameliorative effect crude extract of Haridra cause anti-proliferative activity on the bladder wall of Streptozotacin induced Diabetic Swiss albino mouse of Charles Foster variety Strain code 022. Material and Methods: 50 days aged sixteen healthy mature Swiss albino mice were included in this study for total duration of 6 weeks divided into four groups namely Non diabetic carboxy methyl cellulose vehicle control group, Positive control treated with turmeric extract, Diabetes induced group treated with vehicle and same treated with CMC & turmeric extract. Histological changes were observed in the urothelium and muscle layer after cutting six-micron thick slides which stained by Haematoxylin & Eosin staining. Result: The first group Mice Bladders showed not any progressive changes in the urothelium & muscle layer, the second group mouse bladder urothelium showed apparently not any changes where as third group showed significant proliferative activity in the muscle and urothelium layer in contrast to it the fourth group showed histologically significant anti-inflammatory activity in the same. Conclusion: Crude ethanolic extract of Curcuma longa, which is suitable therapeutic agent for Prameha (Diabetes mellitus) cause significant anti-inflammatory effect in the muscle and urothelium of bladder.

Keywords: Urothelial Distortion, Detrusor muscle Inflammation, Zinziberaceae.