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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

DEVELOPMENT AND VALIDATION OF A METHOD FOR SIMULTANEOUS DETERMINATION OF DAPAGLIFLOZIN AND SAXAGLIPTIN IN A FORMULATION BY RP-UPLC

S. Madhavi* and A. Prameela Rani

ABSTRACT

In the present study, a rapid, an accurate and precise Ultra Performance Liquid Chromatography (UPLC) method was developed and validated for simultaneous estimation of Saxagliptin and Dapagliflozin in its tablet dosage form (10mg Dapagliflozin and 5mg Saxagliptin) by selecting chromatographic parameters. The UPLC method was developed using 2.1 × 100 mm, reverse phase C18 column (Acquity UPLC ethylene bridge hybrid (BEH) C18 1.7 μm) with mobile phases containing 0.1% ortho phosphoric acid and acetonitrile (40:60) as mobile phase. Flow rate was 0.3 ml/min with PDA detection at (λmax) 254 nm and the injection volume was set at 1 μl with run time 3 min. The method was validated by using various validation parameters like accuracy, precision, linearity and robustness. These results show the method could find practical application as a quality control tool for analysis of the drug in its tablet dosage forms in pharmaceutical industries.

Keywords: Saxagliptin, Dapagliflozin, UPLC, Validation, method.

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