AN OPEN LABELLED CLINICAL STUDY TO ACCESS THE SAFETY AND EFFICACY OF SHARBAT-E-EJAZ A POLYHERBAL UNANI FORMULATION IN PATIENTS WITH DRY COUGH
Huma Rafiq*, Sabia, Towseef Amin Rafeeqi, Shaista Urooj and Shabir Bhat
ABSTRACT
Objective: The study aimed to assess the safety and efficacy of a
polyhedral Unani formulation in patients of Dry cough. Background:
Cough is a natural reflex expulsive defence mechanism of the body, for
clearing excessive secretions or inhaled irritants from the respiratory
tract. Dry cough, a common presentation of respiratory diseases is the
most common symptom for seeking medical care as it can adversely
effects the quality of life. Since the drugs available in modern medicine
produce varying adverse effects therefore traditional medicines
including Unani medicine are now being seen with an eye of great
interest and hope. Unani medicine claims to possess effective treatment for the management
of dry cough and suggest an array of medicament for the purpose. Herein we have evaluated
the efficacy and safety of Sharbat-e-jaz, one of the potential Unani formulations in patients
with dry cough. Methods: An uncontrolled open labelled clinical study was conducted on 75
subjects with Dry cough of less than 3 weeks duration. The patients were clinically monitored
for safety and efficacy through 2 weeks of treatment written informed consent was taken
prior to the study and case sheets were maintained separately for each patient. Safety was
assessed on pathological and biochemical parameters whereas efficacy was assessed on
Cough Visual Analogue Scale (VAS). Statistical analysis was done by paired students test.
Results: After two weeks of treatment the efficacy of the drug was significant (p < 0.05) in
the pre and post treatment VAS scores. The test drug has shows an good anti-inflammatory and anti-allergic effect, soothing the respiratory tract and relieving the symptoms. There was an significant reduction in VAS score after two weeks of treatment. There was no adverse effected reported or observed in the studied parameters. Conclusion: The polyherbal formulation was found effective in the management of Dry cough with no side effects reported.
Keywords: Dry cough, Sharbat-e-jaz, Unani System of medicine, Respiratory diseases.
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