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Abstract

ANTI ULCER ACTIVITY OF THE LEAVES OF RAPHNUS SATIVA AND LEUCAS ZEYLANICA

*Roja Pathakota, Santhosh Anasuri, Uma Shankar Damu, Sareesh Kankanala and Madhuri Tekurala

ABSTRACT

The present study was aimed at the investigation of the anti-ulcer activity of the ethanolic and petroleum ether-dichloromethane extracts of the leaves of the traditional Indian medicinal plants Raphnus sativa and Leucas zeylanica at different doses using ranitidine as standard drug. Two methods say alcohol induced ulcers and pyloric ligation were adapted to evaluate the biological potential of the plant extracts using male wistar rat experimental animal models. In both the methods, the extracts were found to possess dose dependant anti-ulcer activity. When compared, the petroleum ether dichloromethane extracts of the both the plants at the dose of 300 mg/kg exhibited significant activity comparable to ranitidine drug. Continuation of the research in this regard is highly recommended for the isolation and the characterization of chief chemical constituents responsible for this pharmacological potential of the extracts.

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