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Armin Eisazaei*, Dr. T. Vithya, Dr. Shobha Rani R. H. and Dr. Shankar Prasad


Background: Adverse drug reactions have proved a significant problem in healthcare for decade. Healthcare professionals have a responsibility in use of rational drugs for their patients. Objectives: The aim of the study was to determine the prevalence of ADRs in a tertiary care hospital to determine the most common Therapeutic Class of Drugs causing ADR and to determine the most common Organ system affected by ADR. Materials and Methods: The Prospective, observational study was conducted in the wards of St. Philomena’s Hospital, Bangalore between January 2016 and August 2016. All Inpatients were monitored for ADRs during their admission period. Results and Discussion: Over the study period of 8 months, a total of 127 ADRs were reported in 124 patients. The ADRs observed were higher in male patients [66 (51.9%)]. A predominance of gastro-intestinal reactions [35 (27.55%)] was observed. Therapeutic classes of drugs frequently associated with ADRs were antibiotics [31(24.40%)] followed by antihypertensive agents [24 (18.89%)] and antiasthmatics [7 (5.51%)]. The most common drugs involved in causing ADRs were Furosemide and Cefoperazone and the most commonly reported ADR was Diarrhoea [11 (8.66%)] followed by Itching [9 (7.08%)]. Majority of the ADRs [95 (74.80%)] were managed by withdrawing the suspected drug. The causality assessment of the ADRs were carried out using the Naranjo’s Scale algorithm and the majority of the ADRs were found to be definite [41 (32%)]. Conclusion: Continuous monitoring by a clinical pharmacist in hospital setup will definitely reduce the occurrence of ADR and improve the patient safety.

Keywords: Adverse drug reaction, Pharmacovigilance, Naranjo scale, Causality assessment, Patient safety.

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