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Abstract

PHYTOCHEMICAL INVESTIGATION AND IN-VITRO ANTHELMINTIC ACTIVITY OF THE LEAVES OF GYNURA LYCOPERSICIFOLIA LINN

*Pulipaka Shankaraiah and Anasuri Santhosh

ABSTRACT

Introduction: The present study is aimed at phytochemical investigation and evaluation of the in-vitro anthelmintic activity of the leaves of the medicinal plant Gynura lycopersicifolia which was not reported earlier in an attempt to develop natural products as safe and effective alternatives for synthetic drugs that possess challenges like, antimicrobial resistance and side effects. Methods: Dried leaves of the plant was used for extraction with water, ethanol and ethylacetate as menstrum and the extracts thus obtained were used for phytochemical qualitative analysis for different phytopharmaceutical agents like alkaloids and flavanoids. The extracts which were found to possess maximum constituents were selected for biological evaluation for anthelmintic activity using Indian earth worms in-vitro. Albendazole was taken as reference standard. Time taken for paralysis and death of the worms was taken as criteria for the efficacy of standard and extracts. Results: Both the ethanolic and ethyl acetate extracts were found to contain various phytochemicals of pharmaceutical importance such as alkaloids and flavanoids. Both the extracts were also known to exhibit anthelmintic activity in-vitro against Indian earth worms at concentrations 30 mg/ml comparable to reference standard 10 mg/ml. Conclusions: Ethanolic and ethyl acetate extracts of the leaves of the plant Gynura lycopersicifolia contains significant phytochemicals of pharmaceutical importance can be used for the biological evaluation for different pharmacological activities. Both the extracts were found to possess significant anthelmintic activity against Indian earth worms in-vitro. More study is required for isolation and characterization of chief chemical constituents responsible for the anthelmintic activity and its in-vivo evaluation.

Keywords: Ethanolic, ethyl acetate extracts, Albendazole, Indian earth worms.


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