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J.Joysa Ruby* and V.P. Pandey


The last two decades have been marked by the recognition of the nasal cavity as a potential route for drug delivery. The nasal route has attracted increasing attention as a suitable method for delivery. The nasal cavity as a site for systemic absorption of drug has some advantages which include large surface area, porous endothelium basement membrane, highly vascularised epithelial layer; high total blood flow per cm3, avoids first pass metabolism and easy access. The novel nasal delivery available is microspheres, microemulsion, liposomes, nanoparticle, In-situ gel etc. Even though a number of challenges are still to be overcome, the encouraging results stimulate pharmaceutical researchers to make further efforts in order to develop new novel nasal formulations to replace the conventional nasal products. The present study is an attempt to investigate the possible novel methods of nasal drug delivery system.

Keywords: novel nasal delivery, microspheres, microemulsion, nanoparticle, In-situ gel.

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