WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

A NEW ANALYTICAL METHOD DEVELOPMENT & VALIDATION FOR THE ESTIMATION OF OLMESARTAN MEDOXOMIL AND CILNIDIPINE IN ITS PHARMACEUTICAL DOSAGE FORM BY UPLC AS PER ICH GUIDE LINES

K. Santhosh Nayak* and K. Pramod

ABSTRACT

A simple, accurate, precise, sensitive, rapid UPLC method has been developed and validated for determination of Olmesartan medoxomil and Cilnidipine in its pharmaceutical dosage form. Chromatographic separation was achieved on a BEH C18 column(100 ×2.1mm,1.7), by a mobile phase consisted of Ph3.5 buffer, maintained with ortho phosphoric acid and methanol in 35:65(V/V) ratio with a flow rate of 0.3 ml/min. The detection wavelength was set at 254 nm. Olmesartan medoxomil and Cilnidipine was subjected to different stress conditions. The degradation products, when any, were well resolved from the pure drug with significantly different retention time values. The method was linear (r = 0.999) at a concentration range of 0.2-0.3μg/ml. The intra and inter day precisions were satisfactory; the relative standard deviations did not exceed 2%. The accuracy of the method was proved; the mean recovery of Olmesartan medoxomil and Cilnidipine was 99.04- 101.58%. The proposed method has high throughput as the analysis involved short run-time (3.20 mins). The method met the ICH/FDA regulatory requirements. The proposed method was successfully applied for the determination of Olmesartan medoxomil and Cilnidipine with acceptable accuracy and precisions; The results demonstrated that the method can be applied successfully for routine use in quality control industry laboratories.

Keywords: Olmesartan medoxomil and Cilnidipine, UPLC.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More