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Abstract

DESIGN AND DEVELOPMENT OF SINGLE CORE OSMOTIC PUMP (SCOP) FOR POORLY SOLUBLE DRUG

Nityanand Zadbuke*, Sadhana Shahi, Rajendra Marathe, Rajesh Nawale and Satish Rojekar

ABSTRACT

The present work aims towards the design and development of
controlled release formulation of poorly soluble drug Carbamazepine
(CBZ) based on osmotic technology by using single core osmotic
pump (SCOP) approach. Carbamazepine (CBZ) is a first-line
antiepileptic drug (AED) drug used for the treatment of partial and
tonic-clonic seizures. The concentrations of Natrosol 250L (rate
controlling polymer) and Sodium chloride (Osmogen) added to the
core tablet were optimized. Cellulose acetate (CA) and Polyethylene
glycol (PEG 8000) were used as semipermeable membrane and pore
former, respectively. The effect of different formulation variables
namely concentration of rate controlling polymer and osmogen in the
core tablet, % pore former, % weight gain, orifice diameter, pH of the dissolution medium
and agitation intensity on the in vitro release was studied. CBZ release was directly
proportional to % of Osmogen and inversely proportional to % of rate controlling polymer in
core tablet. The system was found to deliver CBZ at a zero order rate for 24 h independent of
pH and agitation intensity can be useful as improved AEDs efficacy, tolerability and patient
compliance.

Keywords: SCOP, Natrosol 250L, Cellulose acetate, Osmogen, PEG 8000.


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