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Bhusnure O. G.*, Kendre S. P., Gaikwad V. M., Gholve S. B. and Giram P. S.


The aim of the present investigation was to develop fast disintegrating tablet of Nortriptyline. Fast disintegrating tablet FDT were prepared by direct compression method. Fast disintegrating tablets containing 10 mg of Nortriptyline were manufactured using direct compression method. Experiments were evaluated for effects of formulation parameters like type & concentration of diluents, concentration of superdisintegrating agent and their interactions on Nortriptyline FDT properties, and Mannitol were used as diluents of different properties in addition to sodium starch Glycolate (SSG), and Crospovidone which was used as a natural superdisintegrant in combination with the synthetic. The obtained results revealed that disintegration time of the optimized FDT formula (12.5 sec. ± 40 sec). FDT composed of Sodium Starch Glycolate in superdisintegrants 10% level was chosen as optimized formula, as it showed the lowest disintegration time with the highest drug release up to 87.42%. These tablets provided low disintegration time and high hardness (3.6±0.15) that are acceptable for FDT.

Keywords: Nortriptyline, Superdisintegrants, Sodium Starch Glycolate, Tablet.

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