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Abstract

SYNTHESIS AND ANTIBACTERIAL EVALUATION OF BENZOTHIAZOLE DERIVATIVES

Dr. Rashmi Kumari*, Dr. Brij Bihri Sharma and K. Bhanukiran

ABSTRACT

Benzothiazole nucleus was synthesized by para amino acetanilide, then it is subjected to treatment with various substituted aromatic aldehydes to get the corresponding Schiff’s bases followed by treatment with pthalic anhydride to form 2-(6-acetamidobenzo[d]thiazol-2- ylcarbamoyl)benzoic acid. The structures of synthesized compounds were confirmed by various spectroscopic methods such as IR, 1H NMR and mass spectroscopy. The products were evaluated for their antibacterial activity. Some of the compounds exhibited potent activity when compared with the standards.

Keywords: Benzothiazole, Schiff’s base, Antimicrobial activity, NMR.


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