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Abstract

COMPARATIVE EFFECTS OF CANAGLIFLOZIN AND METFORMIN ON CARDIAC DYSFUNCTION AND TESTICULAR DAMAGE IN DIABETIC RATS

Bosy A. Abd El-Motelp* and Hend A. Sabry

ABSTRACT

Purpose: The current study was carried out to investigate the antidiabetic effect of canagliflozin and metformin on induced cardiac dysfunction and testicular damage in diabetic rats. Methods: Male albino rats were classified into 4 groups. Control group received distilled water(C). Diabetes was induced in second, third and fourth groups rats by feeding them with a high-fat diet(HFD) for 3 weeks followed by intraperitoneal injection of a low dose of streptozotocin (35 mg/kg) and continued with butter supplementation in line with SD for another one week. Second group remained as the untreated diabetic group(D). The third group received orally (10 mg/kg) daily dose of canagliflozin (D + CAN) for 4 weeks. The forth group received orally (100 mg/kg) daily of Metformin (D + MET) for 4 weeks. Results: CAN and MET treatment significantly (P<0.05) increased superoxide-dismutase (SOD), glutathione oxidized (GSSG) activities andglutathione Reduced (GSH) total nitric oxide(TNO)contents with a concomitant decrease in Malondialdehyde (MDA), Interlukin-6 (IL-6) and Tumor necrosis factor alpha(TNF╬▒), lipid profile in both heart and testis tissues. On the other hand, cardiac enzymes C-reactive protein (CRP), Creatine Kinase (CK) and Aspartate aminotransferase (AST) and testicular enzymes Acid phosphatase (ACP), Alkaline phosphatase (ALP), Lactate dehydrogenase (LDH) and total protein showed marked improvement in their levels after treatment with CAN than MET. Conclusion: On conclusions, CAN has the antidiabetic effect and corrects complications associated with diabetes better than metformin such as, cardiac dysfunction and testicular damage. So, Canagliflozin represent a novel therapeutic approach for antidiabetic medications and needed more studies.

Keywords: Diabetes, Canagliflozin, Metformin, Heart, Testis, Rats.


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