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Abstract

INTERMOLECULAR DOMINO MICHAEL-[3+2] CYCLOADDITION THREE-COMPONENT COUPLING REACTIONS: A NEW SYNTHESIS OF 1, 5-DISUSTITUTED TETRAZOLES

Yugandhar Kothapalli, Sridhar Musulla, Mahesh Madala and Srinivasa Rao Alapati*

ABSTRACT

Intermolecular domino Michael-[3+2] cyclo addition reaction is described. Initial azide addition in a Michael fashion to acetylated Baylis-Hillman adducts and followed by reacted with p-toluene sulfonyl nitrile give multifunctional 1,5-disubstituted 1,2,3,4- tetrazoles.

Keywords: Three-component coupling reaction, Baylis Hillman adducts, tetrazoles, p-toluene sulfonylnitrile


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