WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

AN IMMUNOLOGICAL EVALUATION AND STUDY OF DYSBIOSIS ASSOCIATED WITH THALASSEMIC PATIENTS IN BABYLON PROVINCE

Intisar Noori Dawood Alsaluki, Dr. Ifad Kerim Abd Alshibly* and Dr. Muder Hassen Noor

ABSTRACT

Thalassemia is one of the most common genetic diseases in the world and it is a major health problem. It is among the most common genetic disorders worldwide, occurring more frequently in the Mediterranean, Indian subcontinent, Africa and south East-Asia. In Iraq, thalassemia is a major health probl em with prevalence of carrier range from 4.4%- 6.66%. Throughout the past century, there have been an emergence of a large number of diseases, including thalassemia, many of which have been recently associated with intestinal dysbiosis - that is, compositional and functional alterations of the gut microbiome. Dysbiosis may be responsible for a shift in the homeostatic healthy flora to detrimental proinflammatory microbial species, which can later predispose to intestinal inflammation and can drive an autoimmune disease – in particular, a non-gut autoimmune disorder. This study aimed at identifying a possible link between disturbed gut microbiota and the immunological status of patients with thalassemia in Babylon province. Eighty-eight children & adolecents were enrolled in this case – control study. Blood & stool samples were taken from all subjects in the study for biochemical, immunological & microbiological (bacteriological) studies. After demographic data analysis, results presented in the current study established a correlation between the frequency of blood transfusion and acquisition of hepatitis C. also, in the present study bacterial microbiota was assessed among the study groups to reveal a hypothetical association between disturbed microbiota and the immunological status among patients with thalassemia. Results got in our study stated that, there was a significant positive correlation between the distribution of gram negative bacteria (E coli, Klebsiella and Enterobacter) in stool samples of thalassemic patients than controls.

Keywords: thalassemia, microbiota, immune disturbance.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More