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Abstract

MEASUREMENT OF CADMIUM CONCENTRATION IN BLOOD AND FOLLICULAR FLUID TO ASSESS ITS RELATION WITH OOCYTE AND EMBRYO QUALITY IN WOMEN UNDERGOING INTRA CYTOPLASMIC SPERM INJECTION

Shams A. Burhan*, Prof. Dr. Nawal K. Al-Ani and Dr. Muayyad S. Abbood

ABSTRACT

Background: Cadmium, is known to cause opposing reproductive effects, and classified as an endocrine disrupting chemical. Objectives: General population has relatively higher exposure to environmental pollution, the goal in this study is to assess the effect of Cadmium concentration level in blood and follicular fluid on oocyte, embryo quality and pregnancy success in women undergoing ICSI. Patient, Materials and Methods: This study included 70 infertile couples joined in assisted reproductive technology (ART) programs to enter ICSI cycle in high Institute for Infertility Diagnosis and Assisted Reproductive Technologies and Kamal AL-Samarai Hospital, center of fertility and IVF(Baghdad/Iraq) during the period from October 2016 to February 2017. The level of Cadmium concentration will be measured and assess their effect on oocyte and embryo quality. Results: highly significant difference was observed in follicular fluid cadmium (p- value 0.0429, P < 0.05) also there was No-significant difference was observed in blood cadmium(P < 0.05). Blood Cadmium in pregnant there was negatively correlated with (M1, M2, GV, rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer but in no- pregnant group there was positive correlated with (M1,M2,GV,rapture and abnormal) type of oocyte, fertilization rate and number of embryo transfer. Follicular fluid cadmium in pregnant group shows positive correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer and negative correlation with GV, rapture and M1 type of oocyte. Follicular fluid cadmium in no-pregnant there was positive correlation with GV, rapture and M1 type of oocyte and negative correlation with M2 and abnormal type of oocyte, fertilization rate and number of embryo transfer. Conclusions: There was a Significant difference in follicular fluid cadmium between pregnant and no–pregnant. The Increasing number of oocyte lead to increase the fertilization rate, high number of embryo transfer(grade1) this lead to increase chance of pregnancy outcome.

Keywords: Cadmium, oocyte, embryo, ICSI.


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