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Abstract

DEVELOPMENT AND EVALUATION OF PARACETAMOL SUPPOSITORIES

Tara Chand Khatri*

ABSTRACT

Suppositories are supposed to be efficient and effective dosage form
specially to dispense analgesics and antipyretics. Paracetamol is widely
used as antipyretic and analgesic. When used in the form of
suppositories it produces rapid effects due to its quick absorption
through the rectal route. During the present study, Paracetamol
suppositories are formulated by using different ratios of Polyethylene
Glycol 1000 and polyethylene Glycol 4000. The in vitro drug release
rate studies were carried out by using B.P dissolution apparatus. The
average weight variation of different ratios of Paracetamol
suppositories are; 2.5168 gm for the ratio of (3.35-0.65), 2.5193 gm for
the ratio of (3.00-1.00), 2.5308 gm for the ratio of (2.00-2.00), 2.5378
gm for the ratio of (1:00-3.00), 1.83 gm for marketed suppository (Napa). The average
hardness of different ratios of Paracetamol suppositories are; 6.67 kg for the ratio of (3.35-
0.65), 7.21 kg for the ratio of (3.00-1.00), 8.44 kg for the ratio of (2.00-2.00), 8.27 kg for the
ratio of (1:00-3.00), 6.93 kg for marketed suppository (Napa). The melting time of different
ratios of Paracetamol suppositories are; 27 minutes at 37°C for the ratio of (3.35-0.65), 37
minutes at 37°C for the ratio of (3.00-1.00), 1 hour at 37°C for the ratio of (2.00-2.00), 1 hour
and 15 minutes at 37°C for the ratio of (1:00-3.00), 28 minutes at 37°C for marketed
suppository (Napa). The % release of different ratios of Paracetamol suppositories are;
99.05% in 30 minutes for the ratio of (3.35-0.65), 98.53% in 30 minutes for the ratio of (3.00-
1.00), 97.79% in 30 minutes for the ratio of (2.00-2.00), 96.33% in 30 minutes for the ratio of
(1:00-3.00), 99.26% in 30 minutes for the ratio of marketed suppository (Napa) respectively.
It is expected that present work will be helpful for the selection of appropriate ratio of
suppository bases to get the maximum % release of drug.

Keywords: Paracetamol, Uniformity of weight, Hardness, Melting time, Dissolution (In vitro release study).


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