MECHANISTIC EFFECT OF DIETARY COMPONENTS IN MANAGING OBESITY
Dr. Sneharani A. H.*
ABSTRACT
Life style related diseases like obesity, diabetes and cancer threaten the
health worldwide. Attention has been focused recently on the study of
relation between the food/plant derived components and their effect on
target gene to identify the novel pathway involved in the disorder and
their future use as therapeutics. Obesity is a complex multifactorial
disorder associated with many health problems including
hyperlipidemia, hypertension, type2 diabetes, coronary heart disease
and cancer. Obesity is caused by the imbalance between the calories
intake and the expenditure that lead to the pathological growth and
deposition of adipocytes. Adipocytes play a central role in regulating
the adipose mass. In obesity, the increased mass of adipose tissue leads
to the adipose tissue hyperplasia, triggering the transformation of preadipocytes to
adipocytes. The programmed differentiation of preadipocytes to adipocytes is accompanied
by increase in the expression of various transcription factors and adipocyte specific-gene.
This review highlights on the studies to explain the mechanism of action of various dietary
components interacting with proteins involved in adipogenesis.
Keywords: Obesity occurs as a result of genetic and acquired.
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