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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

MECHANISTIC EFFECT OF DIETARY COMPONENTS IN MANAGING OBESITY

Dr. Sneharani A. H.*

ABSTRACT

Life style related diseases like obesity, diabetes and cancer threaten the health worldwide. Attention has been focused recently on the study of relation between the food/plant derived components and their effect on target gene to identify the novel pathway involved in the disorder and their future use as therapeutics. Obesity is a complex multifactorial disorder associated with many health problems including hyperlipidemia, hypertension, type2 diabetes, coronary heart disease and cancer. Obesity is caused by the imbalance between the calories intake and the expenditure that lead to the pathological growth and deposition of adipocytes. Adipocytes play a central role in regulating the adipose mass. In obesity, the increased mass of adipose tissue leads to the adipose tissue hyperplasia, triggering the transformation of preadipocytes to adipocytes. The programmed differentiation of preadipocytes to adipocytes is accompanied by increase in the expression of various transcription factors and adipocyte specific-gene. This review highlights on the studies to explain the mechanism of action of various dietary components interacting with proteins involved in adipogenesis.

Keywords: Obesity occurs as a result of genetic and acquired.

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