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Rameshwar Sahu* and Suman Saha


Nowadays pharmaceutical industries are aiming on development of
sustained release formulations due to its inherent boons. Sustain
release system are considered a wiser approach for the drugs with short
biological half-life and which need to repeated dosing and Matrix type
drug delivery system is a new approaches when developing an oral
controlled release system. Which is providing promising way to
minimize the side effects of drug and cure of the disease is achieved by
preventing the fluctuation of the therapeutic concentration of the drug
in the body. There are several benefits of sustained release drug
delivery over conventional dosage form like improved patient compliance due to less
frequent drug administration, maximum utilization of the drug, increased safety margin of
potent drug, minimize the fluctuation in plasma drug concentration levels, reduction in
healthcare costs and improved the therapeutic effectiveness with shorter period of treatment.

Keywords: Controlled drug delivery, Sustained-release, Matrix system.

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