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Abstract

POLYMORPHIC CHARACTERIZATION OF TRAMADOL HYDROCHLORIDE USING DIFFERENTIAL SCANNING CALORIMETRY

Dushyanth Reddy Vennapu* and M. S. Palled

ABSTRACT

The importance of polymorphism study for regulatory consideration in the pharmaceutical industry is increasing day by day. Polymorphism is defined as the ability of a compound to exist in different crystalline forms in which the molecules have different arrangements in the crystal lattice. Polymorphism is wide spread phenomena observed for most of the drug substances. Different Polymorphs exhibit different mechanical, thermal, physical & chemical properties, such as compressibility, melting point, crystal habit, color, density, dissolution rate & solubility. Polymorphism has great influence on the bioavailability, hygroscopicity, stability, filtration & tableting. Polymorphism can be evidenced by using a variety of experimental techniques ranging from optical microscopy to more sophisticated methods of analysis such as DSC, hot stage polarizing microscopy, x-ray powder diffraction etc.

Keywords: Compressibility, melting point, crystal habit, color, density, dissolution rate & solubility.


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