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Abstract

EVALUATION OF TRANSFORMING GROWTH FACTOR-BETA 1 (TGF-β1) LEVELS IN GCF AND SALIVA DURING INITIAL ORTHODONTIC TOOTH MOVEMENT – AN IN VIVO STUDY

Dr. Femin Pushpan Karyat*, Dr. T. Shobbana Devi, Dr. Valai Kasim Shakeel Ahmed,
Dr. N. R. Krishnaswamy

ABSTRACT

Aim: To determine the changes in concentration levels of Transforming
Growth Factor-β1 (TGF-β1) as a reaction to light continuous
orthodontic forces during initial stage of alignment in Gingival
Crevicular Fluid (GCF) and saliva and also to compare the expression
levels of TGF – β1 in GCF and saliva. Materials and Methods: GCF
and saliva samples were collected from ten healthy subjects (6 females
and 4 males, aged 13-23yrs). The samples were collected at the
following stages:- T0 – Pre Treatment, T1 – 7 days after initiation of
orthodontic treatment, T2 - 30 days after initiation of orthodontic
treatment, disposable micropipettes were used for GCF collection and the saliva samples were
collected in sterile containers. The collected samples were stored in sterile Eppendorf tubes at -
80°C until subjected to ELISA test to determine the concentrations of TGF – β1. Results: The
mean concentration levels of TGF-β1 in GCF was 25.8 + 15.6 pg/ml at T0, 32.5 + 16.1 pg/ml
at T1 and 22.3 + 11.4 pg/ml at T2. The mean salivary concentration levels of TGF-β1 was 22.2
+ 12.2 pg/ml at T0, 30.1 + 15.8pg/ml at T1 and 35 + 13.2 pg/ml at T2. The comparison between
GCF and salivary levels of TGF-β1 (Intergroup) did not show any statistically significant
difference. Conclusion: The light continuous forces applied during initial stage of alignment
brought about changes in the levels of TGF-β1 expression in both GCF and Saliva. There is a
positive indication that saliva could be used as a viable substitute for GCF when used for
assessing bone remodeling in patients undergoing orthodontic treatment.

Keywords: Orthodontic tooth movement; Gingival crevicular fluid; Saliva; TGF-?1.


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