DOCKING STUDIES OF NOVEL 1, 2, 4- TRIAZOLE CONTAINING 1HINDOLE- 2, 3-DIONE ANALOGUES AS ANTICANCER PROPERTIES
C. A. Suresh Kumar*, M. Sundarapandian and S. Venkataraman
ABSTRACT
Cancer is a disease characterized by uncontrollable, irreversible,
independent, autonomous, uncoordinated and relatively unlimited and
abnormal over growth of tissues. 1H-Indole-2, 3-Dioneis an important
class of heterocyclic compound which possess interesting biological
activities like anti-cancer, anti-microbial, anti-fungal, anti-tubercular,
anti-malarial, anti-convulsant, anthelmintic, anti-viral, analgesic and
anti-inflammatory activity. The drugs containing triazole groups were
the first effective chemotherapeutic agents which were systematically
proved for the prevention and cure of bacterial infection in human beings. For the treatment
of cancer, Indoleamine 2, 3-dioxygenase (IDO) is emerging as an important new therapeutic
drug target characterized by pathological immune suppression. Recent understanding of the
molecular pathophysiology of cancer have highlighted that many tyrosine kinases are found
upstream or downstream of epidemiologically relevant oncogenes or tumor suppressor, in
particular the receptor tyrosine kinases. The present research study is focused on the design
of 1H-Indole-2, 3-Dione analogues containing triazole, docking against the known anticancer
targets like indoleamine 2, 3-dioxygenase (IDO) and EGFR tyrosine kinase. Twenty
Five compounds of 1H-Indole-2, 3-Dione analogues were designed and docked against
indoleamine 2, 3-dioxygenase (IDO) and EGFR tyrosine kinase using Auto dock (version
4.2). Among the docked compounds five compounds (Tri1, Tri6, Tri12, Tri16, and Tri20)
were showed a significant docking score against target enzyme compared to the standard. The
present study concluded that 1H-Indole-2, 3-Dione analogues will be a significant lead for
further investigation of anti-cancer properties.
Keywords: 1H-Indole-2, 3-Dione, 1, 2, 4-Triazole, indoleamine 2, 3-dioxygenase, EGFR tyrosine kinase, Anti-cancer properties.
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