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Abstract

PHYTOCHEMICAL ANALYSIS AND EVALUATION OF ANTIDIABETIC ACTIVITY OF MORINGA PTERIGOSPERMA LEAVES IN ALLOXAN-INDUCED DIABETIC RATS

Nishamol K. S.*, Dr. N. A. Aleykutty and Dr. Bindu A. R.

ABSTRACT

The objective of this research was to isolate the flavonoids from the fresh leaves of Moringa pterygosperma Gaertn and evaluated for invivo antidiabetic activity of ethanolic extract and the ethyl acetate fraction on alloxan induced diabetic rat model.The fresh leaves of Moringa pterygosperma Gaertn were subjected to extraction with ethanol in a Soxhlet extractor for 10 hours. The ethanolic extract was fractionated using solvents of increasing polarity like Petroleum ether, benzene, chloroform, ethyl acetate and water. The preliminary phytochemical analysis of each extract revealed the presence of alkaloids, flavonoids, steroids, tannins, saponins and glycosides as major components. The ethyl acetate fraction contains a high percentage of phenolics and flavonoids. The flavonoid isolated by preparative TLC was identified as rutin by HPTLC analysis. The ethanolic extract and ethyl acetate fraction were screened for hypoglycemic efficacy in alloxan induced diabetic rats. Both ethanolic extract and ethyl acetate fraction showed significant hypoglycemic activity as compared to standard drug, metformin. The result obtained in this research work indicated the promising effect of the hypoglycemic potential of ethanolic extract and ethyl acetate fraction as compared to standard metformin. These results clearly showed that flavonoids present in Moringa pterygosperma possesses potent hypoglycemic activity.

Keywords: Moringa pterygosperma Gaertn, Soxhlet extractor, phenolics, flavonoid, rutin, TLC, HPTLC, hypoglycemic, Metformin.


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