HISTOPATHOLOGICAL BIOMARKERS AS INDICATORS OF AQUATIC POLLUTION
Sabiha Khan*
ABSTRACT
There are a number of studies reporting the pathological changes in
fishes exposed to different Organo Chlorine, Organ Phosphorus,
Carbamate and Pyrethroid pesticides. The extent of severity of tissue
damage of particular compound as toxicant depends on its toxic
potentiality in the tissues of organisms. In the present study Gambusia
affinis were exposed to 1/10thsub-lethal concentration (1/10thof LC50
value is 0.0294 ppm) of technical grade chlorpyrifos, (LC50 is 0.294
ppm) for a period of 15, 30 and 45 days. The treated fish groups were
compared with the control group for histopathological changes in liver
and marked changes were observed. The liver showed acute necrosis of hepatocytes and
peribiliary cirrhosis due to Chlorpyrifos, toxicity. The hepatic cellular necrosis was
manifested by fibrosis of hepatic tissues. The liver showed biliary proliferative hyperplasia.
There was severe biliary profierative hyperplasia and the major ducts were greatly distended.
Keywords: Gambusiaaffinis, Chlorpyrifos, Histopathological, Liver.
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