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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

HISTOPATHOLOGICAL BIOMARKERS AS INDICATORS OF AQUATIC POLLUTION

Sabiha Khan*

ABSTRACT

There are a number of studies reporting the pathological changes in fishes exposed to different Organo Chlorine, Organ Phosphorus, Carbamate and Pyrethroid pesticides. The extent of severity of tissue damage of particular compound as toxicant depends on its toxic potentiality in the tissues of organisms. In the present study Gambusia affinis were exposed to 1/10thsub-lethal concentration (1/10thof LC50 value is 0.0294 ppm) of technical grade chlorpyrifos, (LC50 is 0.294 ppm) for a period of 15, 30 and 45 days. The treated fish groups were compared with the control group for histopathological changes in liver and marked changes were observed. The liver showed acute necrosis of hepatocytes and peribiliary cirrhosis due to Chlorpyrifos, toxicity. The hepatic cellular necrosis was manifested by fibrosis of hepatic tissues. The liver showed biliary proliferative hyperplasia. There was severe biliary profierative hyperplasia and the major ducts were greatly distended.

Keywords: Gambusiaaffinis, Chlorpyrifos, Histopathological, Liver.

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