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Abstract

FORMULATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF DULOXETINE HYDROCHLORIDE TRANSDERMAL PATCHES

Dr. P. Shashidhar*, Iffath Afshan*, Dr. M. Sunitha and Dr. D. Ramakrishna

ABSTRACT

In the present research work, an attempt was made to formulate, develop and optimize the Duloxetine Hydrochloride Transdermal Patches. Based on the review of literature polymers Sodium Alginate, HPMC-15cps and Methocel K100 was selected and their FTIR studies gave their compabilities between Duloxetine Hydrochloride and Polymers. Out of ten trials, trial T-5 with Sodium Alginate and HPMC- 15cps and trial T-10 with Methocel K100 and Sodium Alginate was optimized initially. After comparative drug release and physical characterization of trial T-5 and T-10, trial T-10 was optimized and taken for one month accelerated stability studies at 60Co 80%RH. The drug release after one month stability studies from T-10 transdermal patch was found to be 91% after 480 minutes physical measurement thickness was found to be 18mm, with folding endurance test of 190 times and content uniformity was found to be 99.35 percent. Determination of release rate kinetics was also performed for trial T-10, based on R2 value the order of kinetics release of drug follows first with Zero Order with 0.997, followed by Koresmeyer Peppas Plot with 0.984, Higuchis Plot with 0.937 and First Order with 0.900.

Keywords: Duloxetine Hydrochloride, Sodium Alginate, HPMC-15cps, Methocel K100, Zero Order-0.997.


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