FORMULATION, CHARACTERIZATION AND IN-VITRO EVALUATION OF DULOXETINE HYDROCHLORIDE TRANSDERMAL PATCHES
Dr. P. Shashidhar*, Iffath Afshan*, Dr. M. Sunitha and Dr. D. Ramakrishna
ABSTRACT
In the present research work, an attempt was made to formulate,
develop and optimize the Duloxetine Hydrochloride Transdermal
Patches. Based on the review of literature polymers Sodium Alginate,
HPMC-15cps and Methocel K100 was selected and their FTIR studies
gave their compabilities between Duloxetine Hydrochloride and
Polymers. Out of ten trials, trial T-5 with Sodium Alginate and HPMC-
15cps and trial T-10 with Methocel K100 and Sodium Alginate was
optimized initially. After comparative drug release and physical
characterization of trial T-5 and T-10, trial T-10 was optimized and
taken for one month accelerated stability studies at 60Co 80%RH. The
drug release after one month stability studies from T-10 transdermal patch was found to be
91% after 480 minutes physical measurement thickness was found to be 18mm, with folding
endurance test of 190 times and content uniformity was found to be 99.35 percent.
Determination of release rate kinetics was also performed for trial T-10, based on R2 value
the order of kinetics release of drug follows first with Zero Order with 0.997, followed by
Koresmeyer Peppas Plot with 0.984, Higuchis Plot with 0.937 and First Order with 0.900.
Keywords: Duloxetine Hydrochloride, Sodium Alginate, HPMC-15cps, Methocel K100, Zero Order-0.997.
[Full Text Article]