Abstract

EFFECT ON BIO MARKERS OF ALBINO RAT EXPOSED TO ENDOSULPHAN

Sabiha Khan*

ABSTRACT

Acid phosphatase (ACP) and alkaline phosphatase (AKP) are lysosomal enzymes, which catalyse the splitting of phosphoric acid from certain phosphoric esters and commonly found in most tissues of the body. They are generally located on absorptive or secretory surface of cells as membrane bound enzymes. ACP which hydrolysis the ester linkage of phosphate esters at acidic pH 5 to 6 and helps in autolysis of the degenerated cells. The Alkaline phosphatase plays a significant role in phosphate hydrolysis and in membrane transport as well as is a good bio-indicator of stress in biological systems AKP which splits phosphorus esters at alkaline pH (10) and mediates membrane transport and is intimately associated in protein synthesis Interaction of sublethal dose of endosulphan with the enzyme acid phosphatase and alkaline phosphatase in liver and kidney of albino rat was studied for different period of exposure. The enzyme activity was increased due to biliary hindrance and renal failure due to nephrotoxic and hepatotoxic effect. Increase in Acid phosphatase and Alkaline phosphatase activity is due to leakage of lysosomal enzymes and renal and hepatic injury.Endosulphan effects the biomarker of albino rat.

Keywords: Stress, autolysis, hepatotoxic, biomarker. ALT, AST.