EFFECT ON BIO MARKERS OF ALBINO RAT EXPOSED TO ENDOSULPHAN
Sabiha Khan*
ABSTRACT
Acid phosphatase (ACP) and alkaline phosphatase (AKP) are
lysosomal enzymes, which catalyse the splitting of phosphoric acid
from certain phosphoric esters and commonly found in most tissues of
the body. They are generally located on absorptive or secretory surface
of cells as membrane bound enzymes. ACP which hydrolysis the ester
linkage of phosphate esters at acidic pH 5 to 6 and helps in autolysis of
the degenerated cells. The Alkaline phosphatase plays a significant role
in phosphate hydrolysis and in membrane transport as well as is a good
bio-indicator of stress in biological systems AKP which splits
phosphorus esters at alkaline pH (10) and mediates membrane transport and is intimately
associated in protein synthesis Interaction of sublethal dose of endosulphan with the enzyme
acid phosphatase and alkaline phosphatase in liver and kidney of albino rat was studied for
different period of exposure. The enzyme activity was increased due to biliary hindrance and
renal failure due to nephrotoxic and hepatotoxic effect. Increase in Acid phosphatase and
Alkaline phosphatase activity is due to leakage of lysosomal enzymes and renal and hepatic
injury.Endosulphan effects the biomarker of albino rat.
Keywords: Stress, autolysis, hepatotoxic, biomarker. ALT, AST.
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