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Abstract

COMPARATIVE ANTI-INFLAMMATORY ACTIVITY OF PANCHATIKTA GHRTA PREPARED BY THREE DIFFERENT CLASSICAL METHODS AGAINST CARRAGEENAN-INDUCED INFLAMMATION RATS.

Dr. Rajesh Baravaliya*, Dr. Mita Mashru and Dr. Mona Mashru

ABSTRACT

Background: Panchatiktaghrta is an Ayurvedic medicated herbal ghrita formulation mentioned in classics for many diseases particularly for skin disorders and related inflammation. According to Sastra, the ingredients of Panchatiktaghrta formulation possess more tikta, kasaya and kusthaghana and krimighna properties. Various methods are described in texts for preparation of Panchatiktaghrta formulation. Therefore, in the present study Panchatiktaghrta prepared by three different methods namely 1.Sharangadara Samhita (Murchita Ghrita, Panchathikta Kalka, Panchathikta Kwatha) 2.Bhaishajyaratnavali (Murchita Ghrita, Triphala Kalka, Panchathikta Kwatha) 3. Sharangadara Samhita (Amurchita Ghrita, Panchathikta Kalka, Panchathikta Kwatha) and evaluated for its anti-inflammatory activity against carrageenaninduced inflammation in rats. Materials & methods: Comparative efficacy of three different formulations of Panchatiktaghrta formulations were assessed against paw oedema-induced by injecting 0.1ml of 1% (w/v)carrageenan in normal saline into the plantar aponeurosis of left hind limb of rats. Percentage increase in paw volume in comparison to the initial volumes were noted for each rat in test drug administration group and compared with control group for anti-inflammatory activity. Results: All three Panchatiktaghrta formulations produced significant suppression of carrageen an-induced hind paw oedema in rats. PanchatiktaGhrta prepared by. Sharangadara Samhita (Murchita Ghrita, Panchathikta Kalka, Panchathikta Kwatha) produced better suppression of paw oedema (83.17%) followed by PanchatiktaGhrta prepared by Bhaishajyaratnavali (Murchita Ghrita, Triphala Kalka ,Panchathikta Kwatha) (68.27%) and. Sharangadara Samhita (Amurchita Ghrita, Panchathikta Kalka, Panchathikta Kwatha) (62.23%) in comparison to control group. Conclusion: From the present study, it is concluded that PanchatiktaGhrta has an anti-inflammatory activity in experimental model of rats which may attribute to its role in kusthaghana.

Keywords: Panchatikta ghrita, Sharangadara Samhita, Bhaishajyaratnavali, Anti-inflammatory Activity, Carrageenan etc.


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