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Abstract

FORMULATION AND EVALUATION OF SUGAR FREE SUCRALFATE CHEWABLE TABLETS

M. Rajesh*, Blessy Susan Varghese, Bency Susan Varghese, Shaik Shafi Quddin, P. Ramkumar

ABSTRACT

Sucralfate is a cytoprotective drug for treating duodenal ulcer and gastric ulcer. The objective of the study was to develop an effective formulation of sugar free sucralfate chewable tablets thereby decreasing the drawbacks of commercially available suspensions and uncoated tablets of sucralfate and making the formulation suitable for both diabetic and non-diabetic patients. Sugar free sucralfate chewable tablets were prepared by wet granulation method using croscarmellose sodium and sodium starch glycolate as superdisintegrants and neotame as non calorific sweetener. The formulated tablets were evaluated for thickness, hardness, weight variation, friability, disintegration test, drug content, acid neutralizing capacity and in-vitro dissolution studies. The FT-IR spectral studies revealed that there was no interaction between the drug and excipients. Formulation SCT-7 showed rapid drug release (92.3%) at the end of 25 minutes and good acid neutralizing capacity (17.44 mEq) compared to other formulations. Hence the study concludes that formulation SCT-7 containing combination of two superdisintegrants (croscarmellose sodium and sodium starch glycolate) was found to be the better one which satisfied all the criteria for chewable tablets.

Keywords: Chewable tablet, Croscarmellose sodium, Neotame, Sodium starch glycolate, Sucralfate.


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