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WJPR

World Journal of Pharmaceutical Research

( An ISO 9001:2015 Certified International Journal )

An International Peer Reviewed Journal for Pharmaceutical and Medical Research and Technology

Impact Factor : 8.084

ICV : 90.8

WJPR Citation

	All	Since 2011
Citation	2903	2393
h-index	27	24
i10-index	68	60

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Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.

Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

IDENTIFICATION, CHARACTERIZATION AND SYNTHESIS OF IGURATIMOD PROCESS AND DEGRADATION RELATED IMPURITIES

Bharat B. Kashid, Kishor R. More*, Brajesh Sharma and Anil A. Ghanwat

ABSTRACT

A synthesis process developed to produce safe and high purity Iguratimod API. As per regulatory requirement the obtained API subjected to stress test for profiling the plausible impurities and its route of formation. During these studies total of four impurities related to process, forced degradation and OVI were observed. Three of these impurities were detected by HPLC and one by GC. Further these impurities were isolated and subjected to LC-MS, GC-MS and NMR studies. For absolute confirmation these impurities were synthesized and profiled.

Keywords: Iguratimod, methyl impurity, 5-phenoxybenzoic acid impurity, amine impurity, acetaimidine.

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