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Abstract

CO-PROCESSED EXCIPIENTS: AN OVERVIEW

B. Mamatha, D. Srilatha, C. H. Sivanarayani, Prasanna Kumar Desu* and P. Venkateswara Rao

ABSTRACT

This main aim of the current review article is to provide a complete overview on recent development in excipients technology and the approaches involved in development of such excipients. Formulation scientists recognized that single component excipients do not always provide the requisite performance to allow certain active pharmaceutical ingredients to be formulated or manufactured adequately and they have focused their attention on the production of multifunctional excipients with enhanced performance to meet the needs of formulation experts in terms of costs of production, enhanced excipient functionality and quality of tablets. Co-processed excipients help to overcome the deficiencies occurring with the use of general grade excipients. The co-processed excipients retain favourable attributes and are supplemented with new ones. As the chemical change is absent, they are considered to retain the “GRAS” (Generally Regarded as Safe) status. Co-processed excipients are believed to bring a drastic change in the field of pharmaceutical Research. Coprocessing is interesting because the products are physically modified in a special way withoutaltering the chemical structure.

Keywords: Co-Processing, Excipient Technology, pharmaceutical Research, chemical structure.


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