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Amol S. Jagdale* and Sunil V. Amrutkar


Heterocycles are among the most frequently encountered scaffolds in drug and pharmaceutically relevant substances. A heterocyclic core is propitious for variations of substitution pattern during Structure Activity Relationship (SAR). Quinazoline (German-Chinazolin) was first proposed by Weddige. Ketoquinazoline (Quinazolinone) is most important. Quinazoline-4(3H)-ones and its derivatives are versatile nitrogen heterocyclic compounds which have long been known as a promising class of biologically active compounds. Quinazolinone are excellent reservoir of bioactive substances. The stability of the Quinazoline nucleus has inspired medicinal chemists to introduce many bioactive moieties to this nucleus to synthesize new potential medicinal agents. Quinazoline and condensed Quinazoline exhibit potent central nervous system (CNS) activities like anti-anxiety, analgesic, anti-inflammatory and anticonvulsant. Quinazolin-4(3H)-ones with 2, 3-disubstitution is reported to possess significant analgesic, anti-inflammatory and anticonvulsant activities. The synthesis of new compounds which will exert more desired effects with fewer side effects has become an important goal for medicinal chemists.

Keywords: Quinazoline, anti-inflammatory, analgesic.

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