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Abstract

SYNTHESIS AND ANTIMICROBIAL SCREENING OF SOME NEW PYRAZOLINE AND 1,6-DIHYDROPYRIMIDINE DERIVATIVES

Piyush A. Patel, Sandip P. Kakadiya, Heta D. Purohit, Vijay N. Bhadani, Parth V. Bhatt, Dipak M. Purohit*

ABSTRACT

A series of novel Pyrazoline 5a-l and 1,6-dihydropyrimidine 6a-l derivatives have been synthesized as potential antimicrobial agents. The Pyrazoline derivatives 5a-l have been synthesized by reaction of various Chalcones 4a-l with hydrazine hydrate in ethanol. The 1,6- dihydropyrimidine 6a-l were prepared by the reaction of Chalcone (4al) with thiourea in presence of alkaline medium. The structures of the newly synthesized compounds were established on the basis of 1HNMR, Mass, IR spectra and elemental analysis data. All the newly synthesized compounds were screened for their antibacterial activity against E. coli, S. thyphi (Gram-negative bacteria), S. aureus, M. luteus (Gram-positive bacteria) and antifungal activity against Candida albicans (Fungi).

Keywords: Pyrazoline, 1,6-Dihydropyrimidine, Antimicrobial activity, Antifungal activity.


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