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Abstract

FORMULATION DEVELOPMENT AND IN VITRO EVALUATION OF IMMEDIATE RELEASE TABLETS OF LERCANIDIPINE CYCLODEXTRIN COMPLEXES

N. Ravi Sekhar*, Prasanna Kumar Desu, B. Nagendra Babu, P. Venkateswara Rao, B. Anitha

ABSTRACT

Lercanidipine is very slightly soluble in water and present study attempt has been made to prepare and characterize inclusion complex of Lercanidipine with β-Cyclodextrin. The inclusion complexes prepared by different methods viz. Physical mixture, Kneading and Solvent evaporation methods. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.95% drug release in 60 min) of Lercanidipine. Further, the inclusion complexes containing Lercanidipine: β-Cyclodextrin (1:2) was formulated into immediate release tablets which are stable and enhancing in solubility and faster dissolution. For the development of Lercanidipine tablets, the excipients selected were Starlac as diluents, Croscarmellose sodium and Sodium Starch Glycolate, crosprovidon as super disintegrants. The formulation blend was evaluated for Precompression studies and compressed tablets were evaluated for post compression studies and the results were found to be within the limits.

Keywords: Lercanidipine, ?-Cyclodextrin, Crospovidone, Croscarmellose sodium, Sodium starch glycolate.


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