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Abstract

FORMULATION DEVELOPMENT AND EVALUATION OF DIFFERENT FORMULATIONS FOR NERVE GAS POISONING

Radha Sharma*, Suman Jain and Sandhya Jain

ABSTRACT

Organophosphorous (OP) nerve agent poisoning can be treated by muscarinic antagonist i.e. atropine sulphate and reactivator of the inhibited acetylcholinesterase (AChE) i.e. pralidoxime chloride or obidoxime chloride. Obidoxime chloride is being considered more effective against various nerve agents like tabun, sarin and VX. Excipients and storage temperature are important measures to assure safety of parenteral formulations. Type of rubber materials, preservatives and temperature can affect the AChE reactivation potency of the obidoxime chloride and atropine sulphate. In the present study in-vitro reactivation of sarin-inhibited electric eel AChE by obidoxime chloride and atropine sulphate combination were evaluated with different preservatives, with or without phenol and with different polymer septums. In the presence of methyl paraben or benzyl alcohol the average reactivation of AChE by obidoxime chloride was more than 95% in room temperature with the different septum materials, whereas at 50°C the reactivation was lesser than room temperature. Obidoxime chloride in different combinations of preservatives and septums stored at 25oC showed good reactivation as compared to obidoxime chloride stored at higher temperatures (40 and 50°C). The highest reactivation potency was achieved in the combination of methyl paraben and benzyl alcohol.

Keywords: Obidoxime chloride, atropine sulphate, autoinjectors, nerve agents, acetyl cholinesterase.


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