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Muthadi Radhika Reddy*, Dr. M. Sunitha Reddy, Mohammad Shabhana, D. Naresh and A. Jayanthi Reddy


Voriconazole is used to treat invasive aspergillosis and candidiasis and fungal infections caused by Scedosporium and Fusarium species, may occur in immunocompromised patients including people undergoing allogeneic bone marrow transplant, who have hematologic cancers. The purpose of the present study is to formulate and evaluate microspheres loaded topical gel containing voriconazole as a model drug microspheres were prepared by using aqueous ionotropic gelation method. Different polymers, different drug to polymer(s) ratio(s) and other parameters were screened to study their effects on properties of microspheres and to optimize each parameter. The controlled release emulgel was formulated by changing the polymer ratio. FT-IR study confirmed the purity of drug, concede no interaction between the drug and excipients and analyze the parameters affecting the morphology and other characteristics of the resultant products employing scanning electron microscopy (SEM). Microspheres loaded topical gel has been shown that encapsulation and controlled release of voriconazole could reduce the side effect while also reducing percutaneous absorption when administered to the skin. The microspheres obtained were subjected to preformulation studies like bulk density, tapped density, angle of repose, carr’s index, hausner’s ratio the results obtained were with in the limit. The microspheres were characterized by percentage yield, drug entrapment efficiency, Particle size analysis, then the optimized microspheres formulation were incorporated into the gel prepared with various polymer(s) ratio(s) and was evaluated by parameters like Visual inspection, pH measurement, spreadability studies, viscosity and in vitro drug release by using Franz diffusion cell. The result of studied revealed that the optimized batch shows 97.24% release in 12 hours and stable for around there.

Keywords: Voriconazole, Microsphere loaded topical gel, Controlled release, FTIR.

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