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Abstract

FORMULATION AND EVALUATION OF LORNOXICAM TABLET BY PRESS COATING METHOD FOR PULSATILE DRUG DELIVERY SYSTEM

Deepa Kantekar*, K. Divya Lakhmi and H. Padmalatha

ABSTRACT

In the present research work pulsatile drug delivery system of Lornoxicam tablets were formulated by employing compression coating technology. Initially the core tablets were prepared by using various concentrations of super disintegrates, the formulated core tablets were coated with the polymers by using compression coating technology. All the core and press coated tablet formulations were subjected to various physical and chemical evaluation tests for core and press coated tablets. The thickness, hardness and weight variation shown by all the tablet formulations were found within the official pharmacopoeial limits. In vitro release of Lornoxicam of core tablet formulations F1-F3, F1showed faster drug release after 20 mins. Faster drug release can be correlated with the high disintegration and friability observed in this study. The enteric coated formulations C1, C2 showed maximum drug release after 4 hour. C3 and C7showed maximum drug release after 7th hr. Time dependent pulsatile drug delivery system has been achieved from tablet of formulation C7 with 99.9%.

Keywords: Lornoxicam, Super disintegrates, Ethyl cellulose, Pulsatile tablets.


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