WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60


Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here


Track Your Article



Dharmendrasinh V. Dabhi* and Dasharath M. Patel


This study was carried out to formulate Telmisartan Premix containing amorphous state of Telmisartan. Controlled co-precipitation technique is based on solvent-antisolvent precipitation mechanism which is developed in the late 1990s & is covered in detail by Shah et al 2012. This method requires the solubility of compound in polar solvent like N,N-dimethyl acetamide, N,N-dimethyl formamide and N-methyl pyrollidone. Different drug to polymer ratio of 1:1 to 1:3 and Solvent quantity were optimized by factorial design. HPMC AS LF was selected as a polymer based on primary polymer screening. Assay and Residual solvent was selected as dependent variable. Based on factorial outcomes and dissolution studies 1:3 drug to polymer ration was optimized with 75 ml of Solvent. From the results it can be concluded that Telmisartan Premix gives higher dissolution in pH 7.5 i.e 80% drug released within 15 min due to amorphous nature of Telmisartan. Further, 1:10 solvent to antisolvent ration was optimized. Chilled pH 4.5 acetate buffer was selected as antisolvent due to low solubility of Polymer and Telmisartan. To get residual solvent within limit, washing solvent amount optimized to remove residual solvent is 10 ml/gm. One factor at a time (OFAT) strategy is applied to optimized stirrer speed and drying time. Based on XRD and Moisture content results 200 RPM of mechanical stirrer and 12 hrs of drying time optimized. During 6 months accelerated stability studied Telmisartan amorphous state was found.

Keywords: Telmisartan Premix, Solid dispersion, Experimental design.

[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More