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D. Venkatesh* and A. Indhira Revathi


To overcome the disadvantage of extensive first pass effect and low oral bioavailability of carvedilol we designed carvediol buccal tablets by formulation and invitro evaluation of carvediol buccal tablets method so we have proved that carvedilol can certainly be administered through the oral mucosa. Influence of the formulation variables on hardness, drug uniformity, mucoadhesive strength, drug release is evident. Formulation F2 has successfully sustained the release of Carvedilolin buccal cavity, with great mucoadhesive strength. Formulation F2 showed good pre compression and post compression parameters and follows zero order and higuchi kinetics. After the Stability studies the optimized formulation doesn‟t show any remarkable change in drug release. Based on the all experiment results it can be concluded that hydroxy propyl methyl cellulose and sodium alginate containing buccal formulation would be the suitable candidate for mucoadhesive drug delivery of Carvedilol with sustained release properties for the treatment of hypertension., KBr (potassium bromide) disks compressed under a pressure of 150 lbs. The wave number range is selected between 500 - 3500cm-1. Phosphate buffer pH 6.8, Composition of successful f2 formulation of Carvedilol, Hydroxyl propyll methyl cellulose, Guar gum, Acacia, Sodium alginate, Micro crystalline cellulose, Sodium saccharine, Magnesium stearate is 40,50,0,15,30,166.9,0.6,7.5 respectively in mg., Stability studies were performed at a temperature of 25±20c and 65±5%RH and 40±20c and 75±5%RH, over a period of three months (90days) for the optimized buccal tablet, Sufficient number of tablets were packed in amber colored screw capped bottles and kept instability chamber maintained at 400±10C & 75% RH, Results from stability studies indicate that the formulated carvedilol mucoadhesive tablet are stable for a period of 3 months under 2 different conditions at 25±20c and 65±5%RH and 40±20c and 75±5%RH. There were no remarkable changes were observed during the period of storage.

Keywords: Carvediol, ftir, evaluation, formulation, mucoadhesive, buccal.

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