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Abstract

ASSESSMENT OF EFFICACY OF SULPHONYLUREAS AND IN COMBINATION WITH METFORMIN ON GLYCEMIC CONTROL AND LIPID PROFILE OF PATIENTS WITH TYPE 2 DIABETES MELLITUS

T. Tamilselvan*, Amrita Lekshmi V., Anju C. James, Juliya Susan Reji, Namitha Cheriyan and Sojan P. Paul

ABSTRACT

The objective of the study was to assess the efficacy of sulphonylureas and in combination with Metformin on the glycemic control and lipid profile in patients with type 2 diabetes mellitus. This prospective study was carried out for a period of 6 months in patients with age more than 35 years, HbA1C >7% and fasting blood sugar level >140 mg/dl. A total of 84 patients divided into 4 groups based on their treatment. The data obtained were analyzed by using Graph pad Prism version 6.0. The statistical analysis of glycemic control and lipid profile was carried out using Paired student-t test. In monotherapy, treatment with Glimepiride (p<0.05) was more efficacious than Glipizide in reducing hyperglycemia. But, in combination with Metformin, Glimepiride showed more effect on HbA1C (mean reduction 1.22 mg/dl), while Glipizide (mean reduction 58.1 mg/dl) showed more effect on FBS (mean reduction 58.1 mg/dl). The monotherapy with Glimepiride (p<0.05) has a significant effect on lipid profile than Glipizide (p>0.05). When given in combination with Metformin, Glimepiride and Metformin combination had more effect on lipid profile and can be used as the drug of choice in patients with cardiovascular risk.

Keywords: Sulponylurea, Monotherapy, Lipid profile.


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