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Abstract

SYNTHESIS OF SUBSTITUTED SULPHONAMIDE DERIVATIVES AND EVALUATION OF THEIR EFFECT ON SPATIAL MEMORY IN ALZHEIMER’S MODELS

Neeraj Masand*, Satya Prakash Gupta and Ratan Lal Khosa

ABSTRACT

Alzheimer’s dementia is a major cause of disability and mortality and
the typical neuropathological hallmarks of Alzheimer’s dementia are
deposition of protein aggregates/ plaques, formation of neurofibrillary
tangles and neuronal cell death. Lack of effective anti-AD drugs and
drawbacks of present therapeutic option has helped to design a series
of N-substituted aryl sulphonamides derivatives (4a-o). All the
successfully synthesized compounds were evaluated for the treatment
of dementia models i.e. MWM test. The study confirms ability of N-(2-
bromo-4-chloro benzyl) sulphonamide analog with tri-chloro
substitution (4f) as effective anti-AD drug based on its ability to
overcome the deficit during MWM as well as reduced Aβ deposition.

Keywords: Alzheimer’s disease, Morris Water Maze, Aryl sulphonamides, A? deposition.


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