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Sumbul Rafat* and Lakshya Veer Singh


The purpose behind undertaking this project was to formulate and
evaluate gel containing microsponges of Clobetasol Propionate (CP) to
deliver CP in a perennial manner for far-reaching time period to reduce
application frequency, hypersensitive reactions and to improve safety
than conventional formulation. Quasi-emulsion solvent diffusion
method was employed using Ethyl Cellulose as a polymer and
microsponges with varied drug–polymer ratios were prepared. For
optimization purposes, diverse factors affecting microsponges physical
properties were investigated. Microsponges were characterized by
SEM, FT-IR, and for particle size analysis and evaluated for drug
content and drug loading, morphology and in-vitro release study as
well. No chemical interactions were found between drug and polymer used which can be seen
in results of compatibility studies. Drug-polymer ratio manifested luminary effect on
production yield, drug content and drug loading efficiency, drug release and particle size.
SEM results revealed spherical microsponges with porous surface and had 22.09 μm mean
particle size. The best microsponges formulations were then incorporated into carbopol gel
and were evaluated for their viscosity, pH and in-vitro drug release study. The microsponges
gel results depicted that gel formulation G-F4 with 1:1 drug–polymer ratio was more efficient
to give extended drug release upto 75.75 % at the end of 12 h while conventional formulation
exhausted extremely only after 2.5 h. Thus, the formulated microsponge-based gel of
clobetasol propionate would be a likely substitute to conventional therapy for safer and
efficient treatment of inflammation, psoriasis and chronic hyperkeratotic eczema.

Keywords: Clobetasol Propionate, Microsponges, Polymer (Ethyl cellulose), Extended release.

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