WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

NATURAL HISTORY AND RESPONSES TO ANTIVIRAL THERAPIES FOR CHRONIC HEPATITIS B PATIENTS IN SUEZ CITY, EGYPT

Adel A. Hassan*, Mahmoud M. Shedeed, Ahmed G. Salem, Ahmed S. Shalapy, Ahmed Faisal and Mohamed Mosaad

ABSTRACT

Background: The natural history of chronic HBV infection is dynamic, involving a complex interplay between the virus, the hepatocyte and the host immune system. Aim: To improve the management plan of chronic hepatitis B. Patients and Methods: This is a retrospective descriptive study. It included 140 patients with chronic hepatitis B who were following up at the Communicable Disease Research and Training Center during the period between December 2010 and December 2015. Results: Most of patients were in the inactive carrier state representing about 70.2% while patients with active hepatitis represent only 22.8%. The incidence of reactivation was found to be 1.75%/year. Concerning liver cirrhosis; its prevalence was found 18.6% while its incidence was 1.1%/ year. The cumulative 5-years resistance rate to the antiviral drugs was as the follow: Lamivudine (23.9%) while Lamivudine + Adefovir regimen (50%), however no detected resistance for tenofovir. Conclusion: Chronic hepatitis B has a relatively benign course in our region, however regular follow up is recommended due to its dynamic nature and for early detection of its devastating complications. Lamivudine has a fair response rate in our region, unfortunately the response rate to the Adds-On regimen with adefovir was found disappointing, however Tenofovir was found to be highly efficient.

Keywords: Hepatitis B, Natural History, Lamivudine, Tenofovir.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More