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Abstract

A REVIEW: DIPEPTIDYLPEPTIDASE-4 INHIBITORS (GLIPTINS)

Anjum I. Pate*, L, Shadab Khan

ABSTRACT

Dipeptidyl peptidase-4 inhibitors (DPP-4s), also commonly called gliptins. The need of the hour is a refreshing class of drugs whose effects on hyperglycemia can be sustained, without adversely affecting the survival of beta-cells and are weight neutral and free of hypoglycaemia, a true class of anti-hyperglycemics, a dream too good to be true. Classification of gliptins involve 1. Peptidomimetics: Which mimic the DPP-4 enzyme E.g.-vildagliptin and saxagliptin 2. Non- Peptidomimetics-Which those that do not mimic DPP4 enzyme. E.g. Sitagliptin, Alogliptin, Linagliptin. SAR (Structural Activity Relationship), pharmacology, mechanism of action of drugs of gliptin classes are explain in th following review.

Keywords: Dipeptidyl peptidase-4 inhibitors (DPP-4), glucagon-like peptide-1 (GLP-1), type 2 diabetes mellitus (T2DM).


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