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Abstract

A VALIDATED RP_HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF METFORMIN HYDROCHLORIDE & LINGLIPTIN IN ITS BULK AND PHARMACEUTICAL DOSAGE FORM

N. Sudharani*, Manasa Bollepally and Raveendra Babu Konduri

ABSTRACT

A new method was established for simultaneous estimations of Metformin and Linagliptin by RP-HPLC method. The chromatographic conditions were successfully developed for the separation of Metformin and Linagliptin by using Agilent C18 column (4.6 x 150 mm) 5μ, flow rate was 1ml/min, mobile phase ration was (60:40 v/v) Methanol : Ammonium acetate buffer (KH2PO4 and K2HPO4) pH is 3 (pH was adjusted with orthophosphoricacid), detection wavelength was 254nm. The instrument used was WATER HPLC auto sampler, separation module 2695, photo diodearrey detector 996, Empower-Software version-2. The retention time was found to be 2.344 min and 3.284 mins, the % purity of Metformin and Linagliptin was found to be 101.27% and 99.97% respectively. The system suitability parameters for Metformin and Linagliptin such as theoretical plates and tailing factor were found to be 4668, 1.3 and 6089 and 1.2, the resolution was found to be 6.0. The method was precise and rousted.

Keywords: Metformin, Linagliptin, HPLC, Precision, Methanol.


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