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            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
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Abstract

MICROSPHERES: A RELIABLE DRUG DELIVERY SYSTEM FOR ANTICANCER HERBAL DRUGS

*Kripi Vohra, PhD Scholar, Harish Dureja, PhD. and Vandana Garg, PhD.

ABSTRACT

Cancer is a life-threatening disease which severely affects the overall
quality of life of patients. Despite the availability of many
conventional methods of treatment and cytotoxic drugs, their clinical
outcomes are coupled with adverse effects due to their target
unspecific nature. Nowadays, herbal anticancer agents are gaining
special attention as an alternative system of therapy in cancer due to
the benefits associated with them such as minimal adverse effects with
high therapeutic efficacy. However, the barriers restricting their
bioavailability warrant new drug delivery systems which may improve
their pharmacokinetic profile. Recently, formulation of herbal products
using novel drug delivery system (NDDS) has gained popularity due to
the advantages offered by them in comparison to conventional formulations. The present
study reviews the role of microspheres formulated with herbal anticancer extracts or
phytochemicals in treating cancer. Microspheres are one of the NDDSs with discrete
spherical particle size of 1-1000 μm. Their integration to herbal anticancer agents have shown
better patient compliance in terms of route and frequency of administration, improved
efficacy, fewer adverse effects, better solubility and stability, targeted action on tumour cells
and sustained drug release profile. Many studies also support the use of anticancer herbal
microsphere technology in treatment of cancer by exhibiting various benefits.

Keywords: Cancer, herbal, microspheres, plant extracts, phytochemicals, novel drug delivery system.


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