WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

ENHANCEMENT SOLUBILITY OF LOVASTATIN DRUG BY USING LIQUI-SOLID TECHNIQUE

Y. Divya Bharathi* and V. B. Rajesh

ABSTRACT

The present study enlightens to enhance the dissolution profile, absorption efficiency and bioavailability of water insoluble drugs like lovastatin. A novel “Powder Solution Technology” involves absorption and adsorption efficiency, which makes use of liquid medications admixed with suitable carriers and coating materials and formulated into a free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of carrier and coating material. At present 40% of the drugs in the development pipelines and approximately 60% of the drugs coming directly from synthesis are poorly soluble. The limited solubility of drugs is a challenging issue for industry, during the development of the ideal solid dosage form unit. Liqui-solid compacts technique is a new and promising approach to overcome this consequence and that can change the dissolution rate of water insoluble drugs and increase the bioavailability of the drugs. According to the new formulation method of liqui-solid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles can be converted into acceptably flowing and compressible powders by blending with selected powder excipients. It has been speculated that such systems exhibit enhanced release profiles. In this case, even though the drug is in a solid dosage form, it is held within the powder substratin solution or, in a solubilized, almost molecularlydispersed state, which contributes to the enhanced drug dissolution properties.

Keywords: Liquid solid compact, Liquid medications, Non-volatile Vehicles, Dissolution rate.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More