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Abstract

FORMULATION AND EVALUATION OF SUSTAINED RELEASE TABLETS OF MEFORMIN HYDROCHLORIDE

Sandhya Adimulka* and Adukondalu Devandla

ABSTRACT

In this research project, we are assigned a topic to study on the designing of sustained r elease dosage forms and in vitro evaluation of Metformin tablets. The main focus of this research is to develop a better sustained release tablets and conduct all preformulation studies, pre compression and post compression evaluation tests including dissolution test on the tablets to determine the compliance of patient. Dissolution testing is a method for evaluating physiological availability that depends upon having the drug in a dissolved state. The release profiles obtained from in vitro dissolution tests can be used for predicting release kinetics to predict mechanism of drug transport. The effectiveness of such dosage forms relies on the drug dissolving in the fluids of the gastrointestinal tract prior to absorption into the systemic circulation. The rate of dissolution of the tablet is therefore crucial. In this research, our aim s to determine the best formulation among the designed and prepared sustained release dosage form by using an in vitro test method simulating physiological conditions in the GI tract. The dissolution media used closely resembles the GI fluid in the stomach. By conducting various evaluation studies confirmed the best dosage form for sustained release dosage for reduce dosing frequency and improve patient compliance.

Keywords: In-vitro; dissolution test, relese kinetics and Metformin.


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