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Abstract

COMPARISON STUDY SHOWING RATIONAL USE OF OPTIMIZATION METHODOLOGY IN PREDICTING THE BEST POSSIBLE FORMULATIONS OF SUSTAINED RELEASE DOSAGE FORMS

Masheer Ahmed Khan*

ABSTRACT

A computer optimization technique, based on response-surface methodology has proven to be a useful approach for selecting pharmaceutical formulations. The present study examines comparison showing rational use of optimization methodology in predicting the best possible formulations of sustained release dosage forms. Optimization methodology using a factorial design for two factors at three levels (32) which is equivalent to a central composite design (CCD) for two factors was selected to optimize varied response variables viz. release rate exponent (n), k, mean dissolution time MDT and amount of drug released in 12h (Rel12h) in two different drugs, diltiazem hydrochloride and metformin hydrochloride. The optimum formulation was selected using software for both the drugs and the results obtained with the experimental values were compared with the predicted values. Comparison study for both the drugs formulations suggests the rational use of optimization methodology and can be successfully utilized further in other sustained release drug formulations.

Keywords: Optimization, Methodology, Sustained Release.


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