WJPR Citation New

  All Since 2011
 Citation  2903  2393
 h-index  27  24
 i10-index  68  60

Login

Best Paper Awards

World Journal of Pharmaceutical Research (WJPR) will give best paper award in every issue in the form of money along with certificate to promote research activity of scholar.
            Best Paper Award :
Dr. Muhammad Baqir MR Fakhrildin
Download Article: Click Here

Search

Track Your Article

Abstract

IN-VITRO AND IN VIVO ANTI-INFLAMMATORY POTENTIAL OF SILVER NANOPARTICLES SYNTHESIZED FROM CALOTROPIS GIGANTEA LATEX EXTRACT

Pralay Maity, Madhubanti Bepari, Ananya Pradhan, Rathindranath Baral and Sujata Maiti Choudhury*

ABSTRACT

In recent years plant mediated biological synthesis of nanoparticles is
gaining importance due to its simple synthetic procedure and ecofriendliness.
The present study describes in-vitro and in vivo antiinflammatory
activitiesof biogenic stable silver nanoparticles
synthesized by using ethanolic extract of Calotropis gigantea latex (Ag
NPCGs). The silver nanoparticles were previouslycharacterized by
UV-visible spectroscopy, dynamic light scattering (DLS), zetapotential
measurements, Fourier transform infrared spectroscopy and
transmission electron microscopy. The dose-dependent antiinflammatory
activity of silver nanoparticles was assessed by human
red blood cell membrane stabilization, inhibition of protein
denaturation, proteinase and lipoxygenase inhibitory action. The
percentage of HRBC membrane stabilization of Ag NPCGs at 500μg
ml-1 was found to be 75.28%. At the concentration of 500 μg ml-1, Ag
NPCGs showed 74% proteinase inhibitory action. Lipoxygenase
activity was inhibited by Ag NPCGs at the concentration range of 50-500μg ml-1. Ag NPCGs
also exhibited better percentage of inhibition in the carrageenan induced right hind paw
edemathan that of standard drug indomethacin. On the basis of present study, it is concluded
that Ag NPCGs possess potent anti-inflammatory activity.

Keywords: Silver nanoparticles, Calotropis gigantea, Anti-inflammatory activity, Protein denaturation.


[Full Text Article]

Call for Paper

World Journal of Pharmaceutical Research (WJPR)
Read More

Email & SMS Alert

World Journal of Pharmaceutical Research (WJPR)
Read More

Article Statistics

World Journal of Pharmaceutical Research (WJPR)
Read More

Online Submission

World Journal of Pharmaceutical Research (WJPR)
Read More