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Abstract

DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPY METHOD FOR ESTIMATION OF LANSOPRAZOLE

Imran Tadwee*, Pavankumar Ade, Pravin Bhalerao, Arshiya Khan and Dr. Sadhana Shahi

ABSTRACT

The aim of study is to develop and validate simple, accurate, rapid, precise, reproducible and cost effective spectrophotometric method for the quantitative estimation of lansoprazole in a pharmaceutical formulation. The developed UV spectrophotometric method for the quantitative estimation of lansoprazole is based on measurement of absorption maximum wavelength 281.6 nm using pH 6.8 buffer. The stock solution of lansoprazole was prepared, and subsequent suitable dilution was prepared in purified water to obtained standard curve.. Lansoprazole drug showed max at 281.6nm. The calibration curve yielded correlation coefficient (r2 ) of 0.99732. The regression equation was found to be Y=0.0057 x -0.02407 with good linearity. Method is successfully developed and validated as per ICH and can be utilized in quality control analysis of lansoprazole from formulation.

Keywords: Lansoprazole, UV spectroscopy, Analyitcal method development, Validation.


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